Be surprisingly found that the present invention is based on following: connector used in bioconjugates such as antibody-drug conjugates is not inert in the treatment, has an impact to the therapeutic index of bioconjugates. Therefore, the bioconjugates the present invention relates to the method for the therapeutic index for increasing bioconjugates and for treating especially cancer. Bioconjugates according to the present invention have comprising the sulfonamide connector according to the group of formula (1).
