An artificial intelligence (AI) platform, method and program product for detecting and sizing a lesion in real time during a clinical procedure. An AI platform is disclosed that includes: a trained classifier that includes a deep learning model trained to detect lesions and reference objects in image data； a real time video analysis system that receives a video feed during a clinical procedure, uses the trained classifier to determine if a video frame from the video feed has both a lesion and a reference object, calculates an actual size of the lesion based on a pixel size of both the lesion and the reference object, and outputs an indication that the lesion was detected and the actual size of the lesion.
