Disclosed is a waterproof moisture-permeable underwear by which the scope of choices for a material can be widened, and the waterproofness in junction areas can be improved so that staining of an outer garment with urine or menstrual blood leaked from undergarment can be surely prevented. A waterproof moisture-permeable underwear to be worn between undergarment and the outer garment worn on the lower body is constructed by joining a plurality of two-layered fabric pieces (A), each comprising a base fabric (B) disposed facing the undergarment and a waterproof moisture-permeable membrane (C) laminated on a surface of the base fabric (B) facing the outer garment, in junction areas; wherein a material superior to the membrane (C) in texture is selected for the base fabric (B); a material superior to the base fabric (B) in welding property is selected for the membrane (C); and the junction areas (21A-21F) are formed by welding.