The invention relates to the field of chemistry, and more particularly to the field of cosmetics and pharmaceutics, in particular dermatology. More particularly, it concerns a dermatological and/or cosmetic composition for implementing a method for treating sensitive skins and/or skins reactive to fumes, in particular tobacco smoke. The composition contains an active principle consisting of substances inhibiting adhesion effect, induced in particular by said fumes, of human circulating cells, in particular neutrocytes, lymphocytes, monocytes, acidophilic cells, to other cells or molecules of the extracellular matrix, in particular with human keratinocytes. Among the substances antagonists of said adhesion effect, the invention more particularly concerns compositions having as active principle a pyrrolidone-2 arginine carboxylate, in particular pyrrolidone-2 L-arginine carboxylate. The composition has soothing, anti-irritant, anti-inflammatory and anti-ageing effects on the skin.
