NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY;OSAKA UNIVERSITY
发明人:
Toshiro SHIRAKAWA,Yoshiko HASHII
申请号：
US16472210
公开号：
US20190351038A1
申请日:
2017.12.08
申请国别(地区):
US
年份:
2019
代理人:
摘要：
It is an object to provide a combination therapy effective in cancer immunotherapy. The object is achieved by providing an anti-tumor agent, including a transformed Bifidobacterium containing DNA encoding a WT1 protein and DNA encoding a GNB/LNB substrate-binding membrane protein derived from a Bifidobacterium, the transformed Bifidobacterium being designed to display the WT1 protein as an antigen on a surface of the transformed Bifidobacterium, the anti-tumor agent being for use in combination with an immunosuppression inhibitor. The transformed Bifidobacterium can be used as an oral tumor vaccine.
