JUNG SUNG YOUB,KIM DAE JIN,PARK SUNG HEE,WOO YOUNG EUN,CHOI IN YOUNG,KWON SE CHANG
申请号：
ARP120102154
公开号：
AR086969A1
申请日:
2012.06.15
申请国别(地区):
AR
年份:
2014
代理人:
摘要：
The drug ingredients for preventing or treating obesity include various combinations. The combination of oxygenation module and current immunoglobulin region reduces food intake, suppresses gastric emptiness, and promotes lipolysis independent of side effects, which is different from the local oxygenation module, and has strong receptor priming effect and long-term sustainability, Compared with the local oxygen modulation Therefore, it can be widely used in the safe and effective treatment of obesity. Claim 1: a common feature is that it includes oxygen modulation,an immunoglobulin Fc region and a non-peptidyl polymer, wherein the conjugate can be obtained by covalently binding oxyintomodulin to the immunoglobulin Fc region through a non-peptidyl polymer. Claim 4: The conjugate according to claim 3, characterized in that the oxyintomodulin derivative comprises the amino acid sequence of the formula (1): R1-X1-X2-GTFTSD-X3-X4-X5-X6-X7-X8 -X9-X10-X11-X12-X13-X14-X15-X16-X17-X18-X19-X20-X21-X22-X23-X24-R2 (1) where R1 is histidine, deamino-histidyl, dimethyl-histidyl ( N-dimethylhistidyl),B-hydroximidatzopropionilo, 4-imidazoacetelo, b-carboxi imidazopropionilo o tirosina； X1 es AIB (aminosobutirico acid)；d-alanina glicina Sar (N-metilglicina)SERINA or d-serina； X2 is glutamate or glutamate； X3 is leukaemia or thyroid； X4 is SERINA or alanina； X5 is lysine or argina； X6 is glutamate or thyroid； X7 is leukaemia or thyroxine； X8 is aspirin or glutamate； x9 is glutamate, SERINA or a-methylglycolic acid, or has been removed； X10 is glutamine. Glutamate, lysine, amino acid, amino acid or SERINA, or has been deleted； X11 is alachlor, aminoning or diazepam, or has been deleted； X12 is alachlor, aminoning, SERINA or valina, or has been deleted； x13 is lysine, glutamic acid, aminoning or methylglutamic acid, or has been deleted； x14 is aspirin, glutamic acid or leukemia,Or it has been deleted； x15 is phenylacetamide or it has been deleted； x16 is isofluorocaproic acid or diazep
