MACDONALD Lynn,MCWHIRTHER John,TU Naxin,STEVENS Sean,MURPHY Andrew J.
申请号：
SI201331624
公开号：
SI2858487T1
申请日:
2013.03.07
申请国别(地区):
SI
年份:
2019
代理人:
摘要：
Mice, embryos, cells, and tissues having a restricted immunoglobulin heavy chain locus and an ectopic sequence encoding one or more ADAM6 proteins are provided. In various embodiments, mice are described that have humanized endogenous immunoglobulin heavy chain loci and are capable of expressing an ADAM6 protein or ortholog or homolog or functional fragment thereof that is functional in a male mouse. Mice, embryos, cells, and tissues having an immunoglobulin heavy chain locus characterized by a single human V<；sub>；H<；/sub>；gene segment, a plurality of human D<；sub>；H<；/sub>；gene segments and a plurality of human J<；sub>；H<；/sub>；gene segments and capable expressing an ADAM6 protein or ortholog or homolog or functional fragment thereof are also provided.
