Protein kinase conjugates and inhibitors

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专利权人:

Russell Colyn Petter;Arthur Kluge;Deqiang Niu;Lixin Qiao;Roy Lobb;Zhendong Zhu;Juswinder Singh;Shomir Ghosh

发明人:

Juswinder Singh,Russell Colyn Petter,Deqiang Niu,Lixin Qiao,Arthur Kluge,Roy Lobb,Shomir Ghosh,Zhendong Zhu

申请号：

US12882484

公开号：

US09556426B2

申请日:

2010.09.15

申请国别(地区):

US

年份:

2017

代理人:

摘要：

The invention relates to protein conjugates that contain a protein kinase containing a cysteine residue in the ATP binding site and an inhibitor that is covalently and irreversibly bonded to said cysteine residue, such that the activity of the protein kinase is irreversibly inhibited. The invention also relates to compounds that irreversibly inhibit protein kinases.

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中国工程科技知识中心

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http://www.ckcest.cn/home/