Hoerr, Ingmar, Dr.,Pascolo, Steve, Dr.,Von der Mülbe, Florian
申请号：
EP10005375.0
公开号：
EP2216028B1
申请日:
2003.07.03
申请国别(地区):
EP
年份:
2017
代理人:
摘要：
Immunostimulatory agent (A) that contains at least one RNA (I) that has at least one chemical modification, is new. An independent claim is also included for a vaccine containing (A) and at least one antigen (Ag). ACTIVITY : Cytostatic Virucide Antibacterial Fungicide Protozoacide Anti-HIV. MECHANISM OF ACTION : Vaccine immune stimulation. (I) have a strong activating effect on antigen-presenting cells and immune cells, resulting in increased release of cytokines. Murine dendritic cells (DC) were stimulated with 10 Microg/ml of: (a) DNA 1668 or (b) RNA 1668, as phosphorothioate, for 6 days, then concentrations of interleukin (IL)-6 and -12 measured, in ng/ml. For (a) concentrations were about 23 (IL-6) and 2 (IL-12) but for (a) they were 30 and 11, respectively. 5-UCCAUGACGUUCCUGAUGCU (RNA 1668) 5-TCCATGACGTTCCTGATGCT (DNA 1668).
