Refers to tetrahidrofuranilo disubstituted compounds as bradykinin B1 Receptor Antagonists of formula I, wherein R1 is a Group: 3 - amino - pyridine - 5 - il 5 - pirimidinil among others R2 is H, CL, F X is n, CH, enantiomers, Diastereomers, among others.Preferred compounds are: {3 - [2-fluoro-4 - (4 - methoxy - 3 - trifluoromethyl - phenylamino) - bencilcarbamoil] - tetrahydrofuran-3-yl} - amide acid (S) - 2 - oxo - 1.6 - dihydro - 4 - carboxylic pyridazin-3 (S) - 5 - amino - N - {3 - [2-fluoro-4 - (4 - methoxy - 3 - trifluoromethyl - phenylamino) - bencilcarbamoil] - tetrahydrofuran-3-yl} - nicotinamid A, among others. Also refers to a pharmacist.These compounds are useful for the treatment and prophylaxis of acute visceral Pain, neuropathic, among others.SE REFIERE A COMPUESTOS DE TETRAHIDROFURANILO DISUSTITUIDOS COMO ANTAGONISTAS DEL RECEPTOR B1 DE BRADIQUININA DE FORMULA I, DONDE R1 ES UN GRUPO: 3-AMINO-PIRIDINA-5-IL 5-PIRIMIDINIL ENTRE OTROS R2 ES H, CL, F X ES CH, N, ENANTIOMEROS, DIASTEREOISOMEROS, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: {3-[2-FLUORO-4-(4-METOXI-2-TRIFLUOROMETIL-FENILAMINO)-BENCILCARBAMOIL]-TETRAHIDROFURAN-3-IL}-AMIDA DEL ACIDA(S)-6-OXO-1,6-DIHIDRO-PIRIDAZIN-4-CARBOXILICO (S)-5-AMINO-N-{3-[2-FLUORO-4-(4-METOXI-2-TRIFLUORMETIL-FENILAMINO)-BENCILCARBAMOIL]-TETRAHIDROFURAN-3-IL}-NICOTINAMIDA, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO FARMACEUTICO. DICHOS COMPUESTOS SON UTILES PARA EL TRATAMIENTO AGUDO Y PROFILACTICO DE DOLORES VISCERALES, NEUROPATICOS ENTRE OTROS.
