RUDOLF RUCMAN,Rudolf@RuÄŤman,PAVEL ZUPET,Pavel@Zupet
申请号：
SI201100014
公开号：
SI23610A
申请日:
2011.01.13
申请国别(地区):
SI
年份:
2012
代理人:
摘要：
The invention discloses new addition salts of ziprasidone, namely sulfamates and N-substituted sulfamates in amorphous and crystal form and in the form of hydrates. The processes for their preparation comprise the reaction of 1 mol of ziprasidone base with 1 mol of sulfamic acids, and the method for the isolation of these salts in solid form. The invention further comprises a process for the preparation of granulate for tabletting and incapsulation, wherein ziprasidone salt finely distributed on an inert carrier is obtained. According to the invention, the new salts of ziprasidone are used for the treatment and prevention of psychotic disorders and diseases.Izum opisuje nove adicijske soli ziprasidona in sicer sulfaminate in N substituirane sulfaminate vamorfni in kristalni obliki in v obliki hidratovPostopki za njihovo pripravo obsegajo reakcijo mola ziprasidon baze z molom sulfaminskih kislinin metodo za izolacijo teh soli v trdni obliki Izum obsega tudi postopek za dobivanje granulata zatabletiranje in kapsuliranje kjer dobimo sol ziprasidona zelo fino porazdeljeno na inertnem nosilcu V smislu izuma se nove adicijske soli ziprasidona uporabljajo za zdravljenje in preventivo psihotičnih stanj in bolezni
