CHEN, YAN,WAGNER, RICHARD W.,ZHANG, KEMING,RICHALET, PASCALE
申请号：
CA2943242
公开号：
CA2943242A1
申请日:
2015.03.20
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
The present invention provides antigen-binding polypeptides (e.g., bi-specific antigen-binding polypeptides) that specifically bind to a first and a second target antigen with high affinity. The present invention also provides novel antigen-binding polypeptides that specifically bind to HER2 and antagonize HER2 activation. The invention also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen binding polypeptides. Methods of using antigen-binding polypeptide of the invention to treat disease (e.g., cancer) are also encompassed by the invention.
