Chien Hsin Lin;Feng Huei Lin;Hsiang Yin Lu;Yu Te Lin
发明人:
Yu Te Lin,Chien Hsin Lin,Hsiang Yin Lu,Feng Huei Lin
申请号：
US13443115
公开号：
US08889626B2
申请日:
2012.04.10
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention relates to a method for manufacturing a triple cross-linked collagen, which comprises the following steps: providing a soluble collagen sample； mixing the collagen sample with a first cross-linking agent to form a one cross-linked collagen； mixing the first cross-linked collagen with a second cross-linking agent to form a second cross-linked collagen； and mixing the second cross-linked collagen with a third cross-linking agent to form a triple cross-linked collagen, wherein each of the first cross-linking agent, the second cross-linking agent, and the third cross-linking agent is selected from the group consisting of an aldehyde cross-linking agent, an imine cross-linking agent, and an epoxide cross-linking agent. In addition, the first cross-linking agent is different form the second cross-linking agent, and the third cross-linking agent is different form the first cross-linking agent and the second cross-linking agent.
