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Use of Syk tyrosine kinase inhibitors for the treatment of cell proliferative disorders
专利权人:
NOVAREMED LTD.
发明人:
KAPLAN, ELIAHU
申请号:
ES07804842
公开号:
ES2542344T3
申请日:
2007.05.09
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
Compound for use in the treatment of a cell proliferative disorder in a subject, said compound being the S enantiomer of formula I: ** Formula ** in which: the dotted line represents a single or a double bond; R5 and R5 'are independently H or OH; X is -CH2O, -CH2CH2O, -CH (CH3) CH2O or -CH2CH (CH3) O; Z is -CH2CH2O, -CH (CH3) CH2O or -CH2CH (CH3) O; m is 1; and n is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49 or fifty; or a pharmaceutically effective salt thereof in which the cell proliferative disorder is colon cancer.Compuesto para su uso en el tratamiento de un trastorno proliferativo celular en un sujeto, siendo dicho compuesto el enantiómero S de la fórmula I:**Fórmula** en la que: la línea de puntos representa un enlace sencillo o uno doble; R5 y R5' son independientemente H u OH; X es -CH2O, -CH2CH2O, -CH(CH3)CH2O o -CH2CH(CH3)O; Z es -CH2CH2O, -CH(CH3)CH2O o -CH2CH(CH3)O; m es 1; y n es 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49 o 50; o una sal farmacéuticamente eficaz del mismo en el que el trastorno proliferativo celular es cáncer de colon.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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