The purpose of the small organic molecule that has the ability to antagonize the inhibition or the HGF / SF activity or ability to operate or mimic (HGF / SF) active hepatocyte growth factor / scatter factor, the present invention, the molecule , for example, it is useful for recovery or enhancement of blood flow to the (heart after myocardial infarction, for example) or ischemic tissue pro-angiogenic, tissue or organ to promote the healing of a wound or tissue. For example, inhibition of proliferation or growth of cells is beneficial in the treatment of (eg, cancer) (skin disease and inflammatory joint disease, for example) inflammatory disease and abnormal proliferative diseases.本発明は、肝細胞増殖因子/散布因子(HGF/SF)活性を摸倣または作動させる能力、またはHGF/SF活性を抑制または前記に拮抗する能力を有する有機小分子を目的とし、前記分子は、例えば創傷もしくは組織の治癒を促進させる組織または器官の血管新生促進、または虚血組織(例えば心筋梗塞後の心臓)への血流の増強もしくは回復に有用である。細胞の成長または増殖の抑制は、例えば炎症性疾患(例えば炎症性関節疾患および皮膚疾患)および異常増殖疾患(例えば癌)の治療で有益である。
