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НОВЫЙ СТАБИЛИЗАТОР ДЛЯ ФАРМАЦЕВТИЧЕСКИХ БЕЛКОВ
专利权人:
ОКТАФАРМА АГ (CH)
发明人:
ИВАРССОН Эльза (SE),ЭСТЕРБЕРГ Йозефин (SE),РИППНЕР Брита (SE),НИЛЬССОН Ульрика (SE),АГЕРКВИСТ Ирене (SE)
申请号:
RU2012149205/15
公开号:
RU2012149205A
申请日:
2011.04.20
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A method of stabilizing human blood protein or a human plasma protein with a molecular mass greater than 10 kDa melezitose by adding to a solution containing the protein human blood or human plasma protein having a molecular weight of more than 10 kDa.2. The method of claim 1, wherein the solution is brought into the solid state by optionally liofilizatsii.3. A method according to claim 1 wherein the melezitose is contained in an amount of up to 1000 mM, in particular from about 10 mM to about 200 mM, in particular from about 10 mM to about 100 mM.4. The method of claim 1, wherein the protein is human blood plasma or human protein with a molecular mass greater than 10 kDa is a pharmaceutically or biologically significant protein of human blood or blood plasma protein cheloveka.5. A method according to claim 4, wherein the pharmaceutically or biologically significant protein is a recombinantly produced protein is human blood or human plasma protein having a molecular weight of more than 10 kDa.6. A method according to claim 4, wherein the pharmaceutically or biologically significant protein is a human protein or a protein from other sources, such as plants, insects, etc., or mutated, artificial, synthetic, fusion or chimeric protein, or derivative thereof, associated with one or more chemical compounds as well as their sochetaniya.7. A method according to claim 6, wherein the protein is human blood or human plasma protein with a molecular mass greater than 10 kDa is a blood coagulation factor comprising fibrinogen, fibrin monomer, prothrombin, thrombin, FV, FVa, FX, FXa, FIX, FIXa, FVII , FVIIa, FVIII, FXI, FXIa, FXII, FXIIa, FXIII, FXIIIa, von Willebrand factor, ADAMTS13, and derivatives and muteiny.8. A method according to claim 61. Способ стабилизации белка крови человека или белка плазмы крови человека с молекулярной массой более 10 кДа посредством добавления мелицитозы в раствор, содержащий белок крови человека или белок плазмы крови человека с молекулярной м
来源网站:
中国工程科技知识中心
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http://www.ckcest.cn/home/

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