There is a demand for a novel method for manufacturing, with commercial efficiency, a bone-regeneration material that contains calcium phosphate particles in a biodegradable fiber comprising PLGA by using electrospinning, and a novel bone-regeneration material manufactured using the method. According to the present invention, a PLGA resin is heated in a kneader so as to be softened until the viscosity of the resin becomes 102 to 107 Pa·s. A powder of calcium phosphate fine particles is poured while the blade of the kneader is being rotated, and mixed with the softened PLGA resin. The mixture is kneaded by applying thermal and mechanical energy to the mixture through the continuous rotation of the blade of the kneader in the heated state, and aggregations of the calcium phosphate fine particles are disintegrated to prepare a composite in which the calcium phosphate fine particles are dispersed in the PLGA resin. The composite is dissolved by a solvent, and the PLGA resin is completely dissolved by the solvent through agitation for a prescribed period of time to prepare a spinning solution in which the calcium phosphate fine particles are dispersed without being aggregated in a solution having the PLGA resin dissolved therein. Electrospinning is performed on the spinning solution to manufacture biodegradable fibers having therein the calcium phosphate fine particles substantially uniformly dispersed.需要一種使用靜電紡絲法有商業效率的製造骨再生用材料的新方法、以及以該方法製造的新的骨再生用材料,其中,骨再生用材料係由含有磷酸鈣粒子之由PLGA所組成的生物可分解性纖維所組成。在捏合機中加熱PLGA樹脂,使其軟化至樹脂的黏度達到102~107Pa‧s後,一邊使捏合機的葉片旋轉一邊投入磷酸鈣微粒粉體,藉此混合粉體與軟化的PLGA樹脂,使捏合機的葉片在前述加熱狀態下持續旋轉,藉此對前述混合物施加熱能與機械能進行混煉,以打碎磷酸鈣微粒的凝集,進而製備出磷酸鈣微粒分散在PLGA樹脂中的複合體,而後於溶劑中溶解前述複合體並攪拌既定時間,使PLGA樹脂完全被溶劑溶解、且磷酸鈣微粒未凝集的分散在溶解了PLGA樹脂的溶液中,而製備成紡絲溶液,再透過使用該紡絲溶液進行靜電紡絲來製造出一種磷酸鈣微粒大致均勻地分散在其中的生物可分解性纖維。
