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Heterocyclic antagonists of receptors P75
专利权人:
SANOFI
发明人:
ROBERTA AVALLONE,MARCO BARONI,TIZIANO CROCI
申请号:
ARP120104842
公开号:
AR089344A1
申请日:
2012.12.20
申请国别(地区):
AR
年份:
2014
代理人:
摘要:
Claim 2: according to the following selected claim 1, the opposite cube of receiver p75: a) consists of a general formula (1), wherein: m 831717i 8318; represents 0 or 1; a 831717i 8318; represents other formulas (2) and B 831717i 8318; represents hydrogen atom or 831717i 8318; represents hydrogen atom; B 831717i 8318; represents other formulas; (2);W is the heterogenous nitrogen cycle selected from formula group (3);1-3 represents 1, 2 or 3; n⁽I⁾ represents 1 or 2; R¹⁽I⁾ represents a halogen atom, a C₁₋₄ alkyl group,a trifluoromethyl radical, a C₁₋₄ alkoxy group or a trifluoromethoxy radical; R²⁽I⁾ represents a hydrogen atom, a halogen atom, a C₁₋₄ alkyl group,a. Trifluoride group, an alcox c83218c83183248a,a. TFOs, coor 8317 I 8318; or conh832222;R8309l7i 8318; represents the rest of a set of formulas (4),1.2.2.3.2.2.2.2.2.2.2.2.2.2.2.2.2.2.2.2.2.2.2.2.2.2.2.2.2.2.2.2.2.2.2.2.2.2.2.2.2.2.located in any of the available positions, they independently represent a hydrogen atom, a halogen atom, a C₁₋₄ alkyl or C₁₋₄ alkoxy group,a trifluoromethyl or trifluoromethoxy radical, a cyano, or a COOH, COO-C₁₋₄ alkyl group,Conh83222,CONR I R I o NHCOR IR⁽I⁾,e. R8310i8317i 8318; and r83118317i 8318; independently represent a c83218ique group;(b) It is composed of general formula (5), in which: m 831717ii 8318; is 0 or 1; a 831717ii 8318; is other formula (6) and B 831717ii 8318; is hydrogen atom or 831717ii 8318a; is hydrogen atom; B 831717ii 838318318; is other formula (6);R1 8317 II 8318; and RZ 8317 II 8318;which may be identical or different, are independently a hydrogen or halogen atom, a C₁₋₄ alkyl group,Calcium fluoride c8321c83318324;Clu perfluoroalkyl or C₁₋₄ alkoxy or a trifluoromethoxy group; n⁽II⁾ is 1 or 2; R³⁽II⁾ is a remainder selected from the group of formulas (7) in which R⁴⁽II⁾ and R⁵⁽II⁾,which may be identical or different, are located in any of the available positions and are independently a hydrogen or halogen atom, a hydroxyl, a C₁₋₄ alkyl group,Calcium f
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