UNIVERSITY OF IOWA RESEARCH FOUNDATION;FONDAZIONE TELETHON
发明人:
Beverly L DAVIDSON,Yong Hong CHEN,Alberto AURICCHIO
申请号：
US15551869
公开号：
US20180142259A1
申请日:
2016.02.22
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present disclosure provides targeting peptides and vectors containing a sequence that encodes targetting peptides that deliver agents, to the eye. The present inventors have discovered peptides that function to target agents, such as viral vectors, to ocular cells. The present disclosure describes a method to utilize these novel peptides to direct, for example, viral capsids to the cell type of interest. In this instance, ocular cells (such as retinal cells) are targeted by the identified peptides. Vectors harboring capsid proteins modified to include such peptides can be used to provide therapeutic agents to the eye.
