A medical system for determining the individual Fractional Flow Reserve (FFR) value for one or many lesions of interest of a blood vessel, the system comprising an intravascular pressure measurement device for acquiring pressure measurements in the blood vessel during continuous blood flow there through. The pressure measurement device comprises a pressure sensor at its distal portion. The system further comprises an FFR processor adapted to determine the FFR value related to said lesion solely/only based upon the pressure measurements performed by said pressure sensor.