Prevention of protein disulfide bond reduction

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专利权人:

LLC;MedImmune

发明人:

Ahuja, Sanjeev,Chung, Wai Keen,Goldberg, Deborah Sweet,Handlogten, Michael,Narang, Someet,Russell, Brian,Zhu, Min,Hudak, Suzanne,Hwang, Kenneth,Wang, Jihong

申请号：

AU2017262734

公开号：

AU2017262734A1

申请日:

2017.05.09

申请国别(地区):

AU

年份:

2018

代理人:

摘要：

Disclosed are methods for testing the presence and/or activity of glutathione system components and thioredoxin system components during the manufacturing process of disulfide bond-containing proteins. Also disclosed are methods for mitigating reduction of disulfide bonds during the manufacturing process, and for lowering the reduction potential of disulfide bond- containing proteins. Provided are compositions, kits, and methods for mitigating reduction and diminishing reduction potential of disulfide bond-containing proteins during protein manufacturing processes.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/