compound, salt, solid compound, polymorph a, polymorph b, polymorph c, polymorph d, composition, method of inhibiting gls1 activity in a biological sample, methods of treating a gls1-mediated disorder in a subject in need, compound, salt , solvate or polymorph, and use of a compound, salt, solvate or polymorph
GANG LIU,JASON B. BURKE,KANG LE,MICHAEL J. SOTH,PHILIP JONES
申请号：
BR112018012660
公开号：
BR112018012660A2
申请日:
2016.12.21
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
(r) -1- (4- (6- (2- (4- (3,3-difluorocyclobutoxy) -6-methylpyridin-2-yl) acetamido) pyridazin-3-yl) -2- fluorobutyl) -n-methyl-1h-1,2,3-triazole-4-carboxamide and its salt and polymorph forms showing improved exposure following oral dosing. Methods of inhibiting gls1 activity in a human or animal subject are also provided.é revelado aqui o composto (r)-1-(4-(6-(2-(4-(3,3-difluorociclobutoxi)-6-metilpiridin-2-il)acetamido)piridazin-3-il)-2-fluorobutil)-n-metil-1h-1,2,3-triazol-4-carboxamida e suas formas de sais e polimorfos demonstrando exposição melhorada após dosagem oral. também são proporcionados métodos de inibição da atividade de gls1 em um sujeito humano ou animal.
