A connection device and a medical fluid conduit system with such a connection device. A connection device of this kind with a connection body, which has a hose attachment stub and a connector attachment for releasably fastening a further fluid conduit component or fluid storage component, wherein the connection body is coaxially surrounded by a securing sleeve, is known. According to the invention, the securing sleeve can be axially secured on the connection body at two spaced apart securing positions, relative to a central longitudinal axis of the connection body, wherein, in a first securing position, a rotatability of the securing sleeve is permitted and, in a second securing position, a clamping of the securing sleeve on a hose portion plugged onto the hose attachment stub is permitted. Use for medical infusion systems.