INHIBITION SÉLECTIVE DU COMPLEXE D'ATTAQUE MEMBRANAIRE DU COMPLÉMENT ET DE LA C3 CONVERTASE PAR DES COMPOSANTS À FAIBLE POIDS MOLÉCULAIRE DU COMPLEXE SYNTHÉTIQUE D'ACIDE PARAROSOLIQUE TRICARBOXYLIQUE

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专利权人:

AURIN BIOTECH INC.

发明人:

MCGEER, PATRICK,LEE, MOONHEE,GUO, JIAN-PING,SCHWAB, CLAUDIA

申请号：

EP12880850

公开号：

EP2872130A4

申请日:

2012.07.13

申请国别(地区):

EP

年份:

2016

代理人:

摘要：

Selective inhibition of the membrane attack complex of complement in a mammalian species, preferably human, with components of the aurin tricarboxylic acid complex of less than 1 kilodalton in molecular weight. Preferred inhibitors are aurin tricarboxylic acid, aurin quadracarboxylic acid and aurin hexacarboxylic acid. Preferred disease to be treated by elective inhibition of the membrane attack complex of complement are age-related macular degeneration, Alzheimer's disease, atherosclerosis, rheumatoid arthritis, paroxysmal nocturnal hemoglobinemia, malaria infection and multiple sclerosis.

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