GOAD, Mary Elizabeth Pecquet,HASKELL, Melissa M.,SCHRIER, Denis,WOOD, Susan A.
申请号：
AU2013206499
公开号：
AU2013206499A1
申请日:
2013.06.14
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
#$%^&*AU2013206499A120130711.pdf#####Abstract The present invention is directed to methods and compositions for accomplishing systemic delivery of minimally-soluble bioactive agents such as, but not limited to, proteins of the TGF-p superfamily via a peripheral mode of administration. 5 According to the invention, an exemplary bioactive agent is BMP-7. The invention further provides for minimally-invasive systemic treatment of skeletal disorders such as osteoporosis as well as minimally-invasive systemic treatment of injured or diseased non-mineralized tissues and organs such kidneys. Practice of the invention eliminates adverse side effects at the peripheral site of intravenous administration of the bioactive 10 agent. 4422738_i (GHMatters) P87733.AU 1
