An object of the present invention is to provide an HIV replication inhibitor containing an antibody that recognizes human CD4. This object is solved by a human immunodeficiency virus replication inhibitor comprising the following antibody (1) as an active ingredient. (1) As the amino acid sequence of the variable region of the heavy chain, deletion, substitution, or reverse of one to a plurality of amino acids in the amino acid sequence shown in SEQ ID NO: 2 in the sequence listing or the amino acid sequence shown in SEQ ID NO: 2 in the sequence listing An amino acid sequence having at least one mutation selected from the group consisting of position, addition and insertion； and the amino acid sequence of SEQ ID NO: 4 in the sequence listing or SEQ ID NO: 4 as the amino acid sequence of the variable region of the light chain An antibody that recognizes human CD4, comprising an amino acid sequence having at least one mutation selected from the group consisting of deletion, substitution, inversion, addition and insertion of one to a plurality of amino acids in the amino acid sequence described in 1.本発明の目的は、ヒトＣＤ４を認識する抗体を含むＨＩＶ複製抑制剤を提供することにある。該目的は、下記（１）の抗体を有効成分として含む、ヒト免疫不全ウイルス複製抑制剤により解決される。（１）重鎖の可変領域のアミノ酸配列として、配列表の配列番号２に記載のアミノ酸配列又は配列表の配列番号２に記載のアミノ酸配列において１から複数個のアミノ酸の欠失、置換、逆位、付加及び挿入からなる群から選ばれる少なくとも１種の変異を有するアミノ酸配列を含み；かつ、軽鎖の可変領域のアミノ酸配列として、配列表の配列番号４に記載のアミノ酸配列又は配列番号４に記載のアミノ酸配列において１から複数個のアミノ酸の欠失、置換、逆位、付加及び挿入からなる群から選ばれる少なくとも１種の変異を有するアミノ酸配列を含む、ヒトＣＤ４を認識する抗体
