您的位置: 首页 > 农业专利 > 详情页

Cyclic diaminopyridine derivatives as Syk inhibitors
专利权人:
MERCK PATENT GMBH
发明人:
YU, HENRY,DESELM, LIZBETH CELESTE
申请号:
ES12808646
公开号:
ES2552518T3
申请日:
2012.12.18
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
Compounds of formula I ** Formula ** in which it indicates phenylene or 2,3-dihydro-indole-1,6-diyl, each being unsubstituted or monosubstituted with OA, X indicates Hal, Y indicates alkyl having 1, 2, 3 or 4 atoms of C, L1 indicates (CH2) nNR1CO, (CH2) n, NH (CH2) n, OCH2CHOH, NHCO (CH2) n, CO (CH2) nNR1, CONR2, (CH2) nCONR1, O (CH2) pCONR1, NR1CONR3CHR4CONR1, SO2NR1 (CH2) pCONR1 10 or O (CH2) pNR1CO, L2 indicates O (CH2) p, (CH2) nNR1CO, O (CH2) pNR1CO, CHR5NR1CO or CHR3NR4H, CHR3NR4CO, CHR3NR4CO, R2 indicates piperidinyl, piperazinyl, pyrrolidinyl, morpholinyl, 2,3-dihydro-pyrazolyl, 1,2-dihydro-pyridyl or tetrahydropyranyl, each of which is unsubstituted or mono or disubstituted with A and / or>; = O, R3 and R4 together indicate an alkylene chain having 2, 3 or 4 groups CH2, R5 indicates A or benzyl, A indicates unbranched or branched alkyl having 1-10 C atoms, in which 1-7 H atoms can be replaced by F and / or in which one or two non-adjacent CH and / or CH2 groups may be ar replaced by O or N, Hal indicates F, Cl, Br or I, n indicates 0, 1, 2, 3 or 4, p indicates 1, 2, 3 or 4, and pharmaceutically acceptable solvates, salts, tautomers and stereoisomers of the same, including mixtures thereof in all reasons.Compuestos de fórmula I**Fórmula** en la que indica fenileno o 2,3-dihidro-indol-1,6-diílo, estando cada uno de ellos no sustituido o monosustituido con OA, X indica Hal, Y indica alquilo que tiene 1, 2, 3 ó 4 átomos de C, L1 indica (CH2)nNR1CO, (CH2)n, NH(CH2)n, OCH2CHOH, NHCO(CH2)n, CO(CH2)nNR1, CONR2, (CH2)nCONR1, O(CH2)pCONR1, NR1CONR3CHR4CONR1, SO2NR1(CH2)pCONR1 10 o O(CH2)pNR1CO, L2 indica O(CH2)p, (CH2)nNR1CO, O(CH2)pNR1CO, CHR5NR1CO o CHR3NR4CO, R1 indica H o metilo, R2 indica piperidinilo, piperazinilo, pirrolidinilo, morfolinilo, 2,3-dihidro-pirazolilo, 1,2-dihidro-piridilo o tetrahidropiranilo, estando cada uno de los cuales no sustituido o mono o disustituido con A y/u >;=O, R3 y R4 juntos indican una cadena de alquileno que tiene 2, 3 ó 4 gr
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
相关专利

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充