A stent-graft for implantation into a treatment site of a living organism, comprises a scaffold structure for maintaining luminal patency and a graft material secured to at least a portion of the scaffold structure. A biocompatible vehicle is affixed to at least one of the scaffold structure and graft material, and at least one therapeutic agent is incorporated into the biocompatible vehicle for the treatment of a disease condition. The therapeutic drugs, agents or compounds can further reduce a biological organisms reaction to the introduction of the stent-graft to the organism. Various materials and coating techniques can be utilised to maintain the drugs, agents or compounds on the stent-graft device while it is delivered and positioned.
