YI CHEN,TIMOTHY D. CUSHING,JASON A. DUQUETTE,FELIX GONZALEZ LOPEZ DE TURISO,XIAOLIN HAO,XIAO HE,BRIAN LUCAS,LAWRENCE R. MCGEE,ANDREAS REICHELT,ROBERT M. RZASA,JENNIFER SEGANISH,YOUNGSOOK SHIN,DAWEI ZH
申请号：
BRPI0809141
公开号：
BRPI0809141A2
申请日:
2008.03.24
申请国别(地区):
BR
年份:
2014
代理人:
摘要：
Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity. The present invention also enables methods for treating cancers that are mediated, dependent on, or associated with p110 activity, including but not restricted to leukemias, such as acute myeloid leukaemia (AML), myelo-dysplastic syndrome (MDS), myelo-proliferative diseases (MPD), chronic myeloid leukemia (CML), T-cell acute lymphoblastic leukaemia (T-ALL), B-cell acute lymphoblastic leukaemia (B-ALL), non Hodgkins lymphoma (NHL), B-cell lymphoma and solid tumors, such as breast cancer.
