Sunil Paliwal,Gregory A. Reichard,Cheng Wang,Dong Xiao,Hon-Chung Tsui,Neng-Yang Shih,Juan D. Arredondo,Michelle Laci Wrobleski,Anandan Palani
申请号：
US13625799
公开号：
US08796299B2
申请日:
2012.09.24
申请国别(地区):
US
年份:
2014
代理人:
摘要：
A NK1 antagonist having the formula (I),wherein Ar1 and Ar2 are optionally substituted phenyl or heteroaryl, X1 is an ether, thio or imino linkage, R4 and R5 are not both H or alkyl, and the remaining variables are as defined in the specification, useful for treating a number of disorders, including emesis, depression, anxiety and cough. Pharmaceutical compositions. Methods of treatment and combinations with other agents are also disclosed.
