The present invention discloses a method for preparing an aspheric vision correction lens with controllable peripheral defocus. It comprises the steps of: calculating and determining the conditions required for the formation of myopic defocus of a human eye, by examining the shape of the retina of the human eye, the amount of peripheral defocus of the naked human eye or the amount of peripheral defocus of the human eye with a lens; formulating a plan of distribution of the refractive power of the vision correction lens varying with the aperture, according to the conditions obtained for myopic defocus; and making the vision correction lens according to the obtained plan of distribution of the refractive power of the vision correction lens such that after the refractive power of the vision correction lens is added to the human eye, the distribution of the refractive power of the entire eye on the retina is greater in the peripheral region of the retina than in the central region of the retina, and falls in front of the retina, to form myopic defocus. The present invention also discloses a vision correction lens worn outside the eye, an orthokeratology lens and an intraocular lens prepared according to the method. The present invention further discloses a diagnosis and treatment method that utilizes myopic peripheral defocus to control and retard myopia growth.