The invention relates, in part, to non-neonatal Sertoli cells derived from non-rodentanimals, pharmaceutical compositions comprising such Sertoli cells, and usesthereof. The non-neonatal, non-rodent Sertoli cells express more FasL thanneonatal Sertoli cells, and they provide greater immunoprivilege than neonatalSertoli cells. In some embodiments the Sertoli cells are modified to expressa biological factor. In other embodiments, the pharmaceutical compositionsfurther comprise non-Sertoli cells. The invention also provides implantationdevices comprising the pharmaceutical compositions, methods of making thepharmaceutical compositions, and methods of using the pharmaceutical compositionsby administering an effective amount of the compositions.
