A method for treating a target vascular portion of a subject including: providing an angioplasty balloon system including a balloon carrying a first therapeutic agent and a second therapeutic agent on a surface of the balloon, wherein the first therapeutic agent is an anti-proliferative or anti-mitotic agent and the second therapeutic agent is a drug that aids in vascular healing on a surface of the balloon； positioning the balloon proximate the target vascular portion； expanding the balloon to engage the target vascular portion； thereby delivering at least a portion of the active agent to the target vascular portion； and withdrawing the balloon from the subject.
