Methods and systems for identifying blobs, for example kidney glomeruli, are disclosed. A raw image may be smoothed via a difference of Gaussians filter, and a Hessian analysis may be conducted on the smoothed image to mark glomeruli candidates. Exemplary candidate features are identified, such as average intensity AT, likelihood of blobness RT, and flatness ST. A clustering algorithm may be utilized to post prune the glomeruli candidates.
