Gail E. Christie,Priyadarshan Damie,Erin A. Wall,Terje Dokland,Anton Poliakov
申请号：
US15308455
公开号：
US20170049848A1
申请日:
2015.05.06
申请国别(地区):
US
年份:
2017
代理人:
摘要：
L27 in Staphylococcus aureus and other Firmicutes is encoded with an N-terminal extension that is not present in most Gram-negative organisms and is absent from mature ribosomes. We have identified a cysteine protease, conserved among bacteria containing the L27 N-terminal extension, which performs post-translational cleavage of L27. The provided methods have utility for the development of new therapeutic antibiotics that target this novel pathway in order to kill pathogenic Firmicutes and related bacteria.
