As the water soluble medicine can be enclosed efficiently, it is superior in percutaneous absorption, at the same time, it designates that the manner which can produce the constituent and the particular constituent which for the skin include the high-molecular converse micelle whose security is high with simple process is offered as topic. Being the constituent for the skin which includes the high-molecular converse micelle which consists of the parents crocking Characteristic polymer which possesses the hydrophilic segment and the hydrophobic segment, aforementioned high-molecular converse micelle designates the aforementioned hydrophilic segment as the core, designates the aforementioned hydrophobic segment as the shell, possesses the configuration which contains the water soluble medicine. The particular constituent mixes, or, in the oily base, containing the parents crocking Characteristic polymer with the oil phase which becomes and containing the water soluble medicine in the water solvent, the water phase which becomes, with the oily base and contains the parents crocking Characteristic polymer and the water soluble medicine in the water solvent and, it is possible to produce the water phase which becomes by mixing.水溶性薬物を効率よく封入できるとともに、経皮吸収性に優れ、且つ、安全性の高い高分子逆ミセルを含む皮膚用組成物および当該組成物を簡易な工程で製造できる方法を提供することを課題とする。親水性セグメントと疎水性セグメントを有する両親媒性ポリマーからなる高分子逆ミセルを含む皮膚用組成物であって、前記高分子逆ミセルは、前記親水性セグメントをコアとし、前記疎水性セグメントをシェルとし、水溶性薬物を内包した構成を有する。当該組成物は、油性基剤中に、両親媒性ポリマーを含有してなる油相と、水性溶媒中に水溶性薬物を含有してなる水相とを混合するか、または、油性基剤と、水性溶媒中に両親媒性ポリマーおよび水溶性薬物を含有してなる水相とを混合することによって、製造することができる。
