Referring to a metastina Derivative of formula (iv), where V is a group of formula NZ1 - R1 - (P - C = Z2) - NH - chq1 - W1, P (Z1) w2q1 - N - or P - W1 (P ) - N n is 0 OR 1 W1 is n, CH or W2 is n or CH Z1, Z3, Z5 and Z7 C1 - C3 are H or alkyl Z2 Z4 and Z6, Z8 are H or s r1 is H, alkyl C1 C8, among others R2 is H, alkyd ILO C1 - C10, among others R3 is C1 C8 alkyl group, a aralquilo, among others R4 is c1-c4 alkyl,An Aromatic Heterocyclic Group 5 to 14 members with heteroatoms selected from N, o and S, among others Q1 is c1-c4 alkyl Aromatic Group, a Heterocyclic 5 to 14 members with heteroatoms selected from N, o and S, among others Q2 is CH2, NH, or, among others and with csnh ch2nh,,, Z9 h, otherO or s P and P are H or an amino acid residue sequence of SEQ ID no: 1 J1 - J2 - C (J3) (Q3) Y1C (J4) (Q4) y2c (J5) (Q5) Y3C (J6) (Q6) - C (= Z10) J1 is H C1 - C15 alkyl, acyl, C1 - C15, among others or CH2, NH is J2, J3, among others to J6 are H or alkyl C1 - C3 Q3 to Q6 are c1-c4 alkyl, optionally substituted with Oh, amino guanidine Group, among others.These compounds are useful in the treatment of cancer, particularly Prostate Cancer androgen IndependentREFERIDA A UN DERIVADO DE METASTINA DE FORMULA (IV), DONDE V ES UN GRUPO DE FORMULA P-NZ1-R1-(C=Z2)-NH-CHQ1, P-W1(Z1)n-W2Q1- O P-W1(P)n- n ES 0 O 1 W1 ES N, CH U O W2 ES N O CH Z1, Z3, Z5 Y Z7 SON H O ALQUILO C1-C3 Z2, Z4, Z6 Y Z8 SON H O S R1 ES H, ALQUILO C1-C8, ENTRE OTROS R2 ES H, ALQUILO C1-C10, ENTRE OTROS R3 ES ALQUILO C1-C8, UN GRUPO ARALQUILO, ENTRE OTROS R4 ES ALQUILO C1-C4, UN GRUPO HETEROCICLICO AROMATICO DE 5 A 14 MIEMBROS CON HETEROATOMOS SELECCIONADOS DE N, O Y S, ENTRE OTROS Q1 ES ALQUILO C1-C4, UN GRUPO HETEROCICLICO AROMATICO DE 5 A 14 MIEMBROS CON HETEROATOMOS SELECCIONADOS DE N, O Y S, ENTRE OTROS Q2 ES CH2, NH, O, ENTRE OTROS Y ES CONH, CSNH, CH2NH, ENTRE OTROS Z9 ES H, O O S P Y P SON H O UN RESIDUO DE AMINOACIDO DE SECUENCIA SEQ ID NO:1 J1-J2-C(J3)(Q3)Y1C(J4)(Q4)Y2C(J5)(Q5)Y3C(J6)(Q6)C(=Z10)- J1
