WUXI BIOLOGICS (CAYMAN) INC.;OPEN MONOCLONAL TECHNOLOGY, INC.
发明人:
ZHENG, Yong,LI, Jing,CHEN, Zhisheng
申请号：
PE2018000225
公开号：
PE20181018A1
申请日:
2016.08.11
申请国别(地区):
PE
年份:
2018
代理人:
摘要：
The invention refers to an antibody or an anti-virus combined fragment thereof, which includes a series of heavy chain chlorinated paraffin, including: CID NOS: 1.3.5, 13.15, 21, 23, 25, 33, 35 and 37, and a series of light chain chlorinated paraffin, including: 7.9, 11, 17, 19, 27, 29, 31, 41, 43. Page: 1 It also pointed out that the antibody can specifically bind to PD-1 human, and block the alliance by inducing the production of IL-2 products in t-cd4 + cells. It also mentions a kind of PVC, a vector including PVC,A cell phone includes a vector and a dumb cell phone It refers to a pharmacological synthesis including antibodies or polymers to antigens. Through the regulation of human immune function, it is useful for the treatment of multifunctional cancer.La presente invencion refiere un anticuerpo o un fragmento de union a antigeno del mismo, que comprende secuencias de CDR de cadena pesada seleccionadas del grupo que consiste en: SEC ID NOs: 1,3,5,13,15,21,23,25,33,35 y 37, comprende tambien secuencias de CDR de cadena ligera seleccionadas del grupo que consiste en: 7,9,11,17,19,27,29,31,39,41,43 y 65. Tambien refiere que el anticuerpo es capaz de unirse especificamente a PD-1 humana, bloqueando la union a su ligando induciendo la produccion de IL-2 en celulas T CD4+,entre otros modos. Tambien refiere a un polinucleotido, un vector que comprende el polinucleotido, una celula que comprende el vector y una celula huesped. Refiere una composicion farmaceutica que comprende al anticuerpo o fragmento de union a antigeno. Es util para el tratamiento de canceres multiples mediante la modulacion de la funcion inmune humana.
