Infant formulas that include at least one human milk oligosaccharide selected from 2′-fucosyllactose (2′-FL) and lacto-N-neotetraose (LNnT), polyunsaturated fatty acids (PUFAs) docosahexaenoic acid (DHA) and arachidonic acid (AA), where the AA and DHA are present in an n-6/n-3 ratio of between 1 and 1.8, at least 30 mg/L of nucleotides, where the nucleotides include inosine monophosphate, and at least 30 μg/L of lutein are disclosed. Also provided are methods of use of the infant formulas for improving at least one of cognition, learning, and memory in an infant. The methods include administering the infant formulas to an infant.
