N- (ARYLAMINO) SULPHONAMIDE DERIVATIVES INCLUDING POLYMORPHS AS MEK INHIBITORS AS WELL AS COMPOSITIONS, METHODS OF USE AND METHODS FOR PREPARING THE SAME
JEAN-MICHEL VERNIER,COLIN EDWARD ROWLINGS,JEAN-LUC GIRARDET,STUART DIMOCK,BARRY QUART,JEFFREY N. MINER
申请号：
BRPI0815659
公开号：
BRPI0815659A2
申请日:
2008.07.28
申请国别(地区):
BR
年份:
2014
代理人:
摘要：
This invention concerns N-(2-arylamino) aryl sulfonamide compounds which are inhibitors of MEK including crystalline polymorphic forms which exhibit a specific powder x-ray diffraction profile and/or a specific differential scanning calorimetry profile. This invention also concerns pharmaceutical compositions comprising the compounds described herein and methods of use of the compounds and compositions described herein, including the use in the treatment and/or prevention of cancer, hyperproliferative diseases and inflammatory conditions. The invention also concerns methods of making the compunds and compositions described herein.
