DERIVADOS ANTIBACTERIANOS PIRROLIDIN-2-ONA ANULARES

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专利权人:

ACTELION PHARMACEUTICALS LTD.

发明人:

申请号：

ARP160102619

公开号：

AR105839A1

申请日:

2016.08.26

申请国别(地区):

AR

年份:

2017

代理人:

摘要：

Claim 1: a compound of formula (1) where X is Sulfur or CH = CH r\u00b9 represents h, po\u2083h\u2082, so\u2083h, fosfonooximetilo or group of formula (2), where R\u00b2 alquilamino c\u2081\u208b\u2084alquilo c\u2081\u208b\u2084 represents alkyl, dialkyl c\u2081\u208b\u2084amino c\u2081\u208b\u2084, fosfonooxi alkyl c\u2081\u208b By Land., fosfonooximetoxi, 2 - (fosfonooxi - c\u2081\u208b\u2084 alkyl phenyl) - 2 - [(fosfonooxi - alkyl c\u2081\u208b\u2084) phenyl] - alkyl c\u2081\u208b\u2084,Or (2) - (fosfonooxi) - phenyl) - alkyl c\u2081\u208b\u2084 M is one of the groups of formula (3) and (4), where a represents a link or c\u00bac r\u00b9a represents H or Halogen r\u00b2a represents H or r\u00b3a represents h, halogen, alkoxy c\u2081\u208b\u2083 c\u2082\u208b\u2084 Hydroxy, alkoxy -, Hydroxy - Rent c\u2081\u208b\u2084, 1.2 - dihidroxietil Or, (3 fluoroazetidin - 1 - yl) methyl fluoro - 1, 3 - (3 - oxetan - il) azetidin - 3 - ILO - fluoro - 1, 3 - methyl - 3 - azetidin - ilo(4 - hydroxy - 3 - methyl - 1 - il fluoropiperidin), (- 3.3 - 4 - hydroxy - 3 - methyl difluoropiperidin (IL) - 1, 3 - hidroxiazetidin - yl) methyl 3 - (W - hydroxy alkyl c\u2082\u208b\u2084) - azetidin - 1 - 1 - (ILO, oxetan - 3 - il) azetidin - 3 - 1 - (ILO, oxetan - 3 - methyl - 3 - ilo) azetidin or (hidroxipiperidin - 4 - 1 - yl) methyl and r\u00b9b represents amino alkyl Or c\u2081\u208b\u2083, - 1 - 1 - amino - cicloprop ILO, trans 2 - (dimetilaminoacetoximetil) - cicloprop - 1 - ilo1 - (2 - dimetilaminoacetoximetil cicloprop - yl) - 1, 1 - (3 - hidroxiazetidin) - 1 - carboniloximetilo, cicloprop - Hydroxymethyl - 1 - 1 - yl, trans - 2 - Hydroxymethyl - cicloprop ILO - 1 - 1 -, 2 - cicloprop fluoro - Hydroxymethyl - ILO - 1, 2 - fluoro 2 - Hydroxymethyl - cicloprop - yl - 1, 1 - {[2 - (alkyl fosfonooxi - c\u2081\u208b\u2084) - phenyl) - alkyl c\u2081 \u208b\u2084] carboniloximetil} cicloprop - ILO - 1, 1 - {[2 - (alkyl fosfonooxi - c\u2081\u208b\u2084) phenyl] - i cicloprop carboniloximeti

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