Nyomi V. Yam,Iran Reyes,Nipun Davar,Atul D. Ayer,Julie Lee,Sonya Seroff,Suneel K. Gupta,Gayatri Sathyan
申请号：
US12428422
公开号：
US09393192B2
申请日:
2009.04.22
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Dosage forms and methods for providing a substantially ascending rate of release of paliperidone or risperidone are provided. The sustained release dosage forms provide therapeutically effective average steady-state plasma paliperidone or risperidone concentrations when administered once per day. This once-a-day dosing regimen results in only one peak plasma paliperidone or risperidone concentration occurrence in each 24 hour period. In addition, the peak plasma paliperidone or risperidone concentration occurs at a later time following dose administration and exhibits a lesser magnitude than the peak plasma paliperidone or risperidone concentration that occurs following administration of paliperidone or risperidone in an immediate-release dosage form.
