Patrick G. Harran;Hidetaka Suzuki;Xiaodong Wang;Jef K. De Brabander;Lin Li;Ranny Mathew Thomas
发明人:
Patrick G. Harran,Xiaodong Wang,Jef K. De Brabander,Lin Li,Ranny Mathew Thomas,Hidetaka Suzuki
申请号：
US13022033
公开号：
US08143418B2
申请日:
2011.02.07
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Caspase activity and apoptosis are promoted using active, dimeric Smac peptide mimetics of the general formula M1-L-M2, wherein moieties M1 and M2 are monomeric Smac mimetics and L is a covalent linker. Target cancerous or inflammatory cells are contacted with an effective amount of an active, dimeric Smac mimetic, and a resultant increase in apoptosis of the target cells is detected. The contacting step may be effected by administering to a pharmaceutical composition comprising a therapeutically effective amount of The compoundic mimetic, wherein the individual may be subject to concurrent or antecedent radiation or chemotherapy for treatment of a neoproliferative pathology.
