The present invention relates to a pharmaceutical composition for topical administration and a preparation method thereof. In particular, the invention relates to a pharmaceutical composition comprising (3aR,5s,6aS)-N-(3-methoxy-1,2,4- thiadiazol-5-yl)-5-(methyl(7H-pyrrolo[2,3-d]pyrimidine-4-yl)amino)hexahydrocyclopenta[c]pyrrole-2(1H)-carboxamide or a pharmaceutically acceptable salt thereof, and diethylene glycol monoethyl ether.本發明關於一種局部給藥的藥物組合物及其製備方法。具體而言，本發明關於一種含有(3aR,5s,6aS)-N-(3-甲氧基-1,2,4-噻二唑-5-基)-5-(甲基(7H-吡咯並[2,3-d]嘧啶-4-基)胺基)六氫環戊並[c]吡咯-2(1H)-甲醯胺或其可藥用鹽，和二乙二醇單乙醚的藥物組合物。
