PROBLEM TO BE SOLVED: To provide means that allows permeation of active ingredient in the skin.SOLUTION: Provided are: a particle having the following characteristics: (a) containing a cellulose derivative and an active ingredient (b) the active ingredient is contained inside the particle and (c) the volume distribution average particle diameter is 1 to 1000 nm, and a method for producing particle including mixing (i) an organic solvent containing a cellulose derivative and (ii) an aqueous solution containing an active ingredient as a mixed liquid of an organic solvent and an aqueous solution so that a W/O type dispersion is formed, to precipitate particle.SELECTED DRAWING: NoneCOPYRIGHT: (C)2018,JPO&INPIT【課題】皮膚における有効成分の透過を可能にする手段を提供すること。【解決手段】以下の特性を有する、粒子:(a)セルロース誘導体および有効成分を含む;(b)有効成分が粒子内部に含まれる;ならびに(c)体積分布平均粒子径が1~1000nmである。 (i)セルロース誘導体を含む有機溶媒と(ii)有効成分を含む水溶液とを、有機溶媒および水溶液の混合液としてW/O型分散液が形成されるように混合して、粒子を析出させることを含む、粒子の製造方法。【選択図】なし
