A pharmaceutical composition for treating cholangiocarcinoma, a method for inhibiting growth or invasion of cholangiocarcinoma and a method for treating cholangiocarcinoma
Korea Research Instititute of Bioscience and Biotechnology
发明人:
Hong, Hyo Jeong,Lee, Eung Suck,Son, Yeon Sung,Lee, Jung-Whoi,Kim, Jin Man
申请号：
AU2007288620
公开号：
AU2007288620B2
申请日:
2007.08.23
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
Disclosed herein are a pharmaceutical composition for inhibiting the growth or metastasis of cholangiocarcinoiria, comprising a LlCAM activity inhibitor or expression suppressor and a treatment method using the composition. This is based on the finding that LlCAM is overexpressed on cholangiocarcinoma and plays an important role in the growth and metastasis of cholangiocarcinoma and the mortality of cholangiocarcinoma patients increases as the expression rate of LlCAM increases. Also, antibodies inhibitory of the activity of LlCAM, or siRNAs suppressing the expression of LlCAM, are found to reduce the growth and invasion of cholangiocarcinoma cells. Mouse monoclonal antibodies, recognizing the LlCAM protein on the cholangiocarcinoma cell surface and binding specifically to cholangiocarcinoma tissues, or siRNAs, antisense oligonucleotides or shRNAs, may be useful in the treatment of cholangiocarcinoma by inhibiting the growth, invasion and migration of cholangiocarcinoma cell.
