Yan Yang,Sreekala Mandiyan,Brett Robinson,Lida Kimmel,Yaron Hadari,Timothy David Jones,Francis Joseph Carr,Robert George Edward Holgate,Richard Weldon
申请号：
US15558306
公开号：
US20180057595A1
申请日:
2016.03.15
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Provided herein are compositions, methods and uses involving antibodies that specifically bind to MET, a receptor tyrosine kinase, and modulate the expression and/or activity of MET. Also provided are uses and methods for managing, treating, or preventing disorders, such as cancer. In one aspect, provided herein is a monoclonal antibody or antigen-binding fragment thereof that binds to the Sema/PSI domain of human MET. Also provided herein is a kit comprising an antibody or antigen-binding fragment provided herein. Also provided herein is a method of managing, protecting against, or treating cancer in a subject, comprising administering to a subject in need thereof a therapeutically effective amount of an antibody or antigen-binding fragment provided herein.
