The present invention relates to the methods of improved composition and treatment disease, such as cancer, there is provided combination therapy TGF beta receptors (TGF β R) antagonist includes domain antibodies and cellular immunotherapy, particularly, in the T cell receptor (TCR) of cellular immunotherapy immunological regulation expression Chimeric antigen receptor (CAR) or modification. It include combination therapy the invention additionally relates to polynucleotides, expression vector and immunity regulatory cell, and the method for generating the immunity regulatory cell.
