Karl-Heinz Heider,Anke Baum,Charlotte Astrid Russell
申请号：
US13894743
公开号：
US08992915B2
申请日:
2013.05.15
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates to immunotherapies that are based on depletion of CD37-positive cells such as B-cells. The present invention provides methods for reduction of CD37-positive cells such as B-cells in an individual/patient using a combination of CD37 antibody/antibodies and ICE. The combination of CD37 antibodies and ICE is shown to have improved anti-tumor efficacy compared to single agent treatment. The application further provides materials and methods for treatment of diseases involving aberrant B-cell activity.
