Modulators of ABC transporter and cystic fibrosis transmembrane conductance regulator (CFTR)

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专利权人:

VERTEX PHARMACEUTICALS INCORPORATED

发明人:

BINCH, HAYLEY,GROOTENHUIS, PETER, D

申请号：

NZ58387808

公开号：

NZ583878A

申请日:

2008.09.15

申请国别(地区):

NZ

年份:

2012

代理人:

摘要：

The present disclosure relates to compounds of formula (IVA) which are modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith, wherein the variables shown in formula (IVA) are as defined in the specification. The disclosure also relates to methods of treating ABC transporter mediated diseases using such modulators.

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